卢宇
卢宇，博士、研究员，河北农业大学兼职博士生导师、南京农业大学和江苏大学兼职硕士生导师。现任江苏省农业科学院动物免疫工程研究所副所长、动物疫苗制剂工程创新团队负责人、江苏省免疫学会兽医免疫专业委员会副主任委员、江苏省畜牧兽医学会副理事长、农业农村部兽药评审中心第一届兽药评审咨询专家库专家，江苏省第十二批“六大高峰人才”。主要从事动物生物制品的佐剂、热稳定剂和无针皮内免疫新技术、新产品的研发。先后主持承担多项国家、省部级课题，主持获得新兽药证书1件，国家发明专利授权18项、PCT专利2项，神农中华农业科技奖二等奖1项、江苏省科学技术奖二等奖1项，以第一作者/通讯作者发表论文50余篇，参编（译）著作5部。
一、主持科研项目:
1. 鸡传染性法氏囊病毒VP4和VP5蛋白抑制机体I型干扰素信号通路的探索，国家自然科学基金，2013-2015；
2. 猪免疫抑制性瘟病辩证施治关键技术研究与示范，农业部公益性行业专项子课题，2014-2018；
3. 猪圆环病毒疫苗新型水包油佐剂的开发，江苏省农业科技自主创新资金，2013-2015；
4. 活疫苗室温保存技术的研究，江苏省六大人才高峰项目，2015-2017；
5. 猪鸡重要冠状病毒免疫技术创新,江苏省重点研发计划，2020-2024
6. 动物流感病毒跨种传播亚型疫苗制造技术创新与应用，江苏省农业科技自主创新资金，2022-2025
二、获得专利授权（第1完成人）
1.一种复方免疫佐剂及疫苗，ZL 201010190806.3；
2. 囊素样多肽衍生物作为复方猪瘟疫苗免疫增强剂的应用，ZL 201310489683.7；
3. 一种耐热保护剂及其应用, ZL 201310004607.2；
4. 鹅细小病毒及其应用，ZL 201310489683.7；
5. 兽用药物的复乳型载体及其应用，ZL 2014106076752；
6. 一种环糊精酯化衍生物、制备方法及其应用，ZL 2014103463984；
三、代表性论文：
1. A chimeric porcine reproductive and respiratory syndrome virus 1 strain containing synthetic ORF2-6 genes can trigger T follicular helper cell and heterologous neutralizing antibody responses and confer enhanced cross-protection, Veterinary Research 2024
2. Alginate di-aldehyde modified metal-organic framework nanocarriers as delivery and adjuvant in inactivated pseudorabies vaccination, Materials Horizons 2024
3. Formulation and evaluation of lipidized imiquimod as an effective adjuvant, ACS Infectious Diseases 2023
4. Dermal microvascular units in domestic pigs (Sus scrofa domestica): Role as transdermal passive immune channels, Frontiers in Veterinary Science 2022
5. Optimization of heat-resistance technology for a duck hepatitis lyophilized live vaccine, Vaccines 2022
6. Effect of multiplicity of infection on the evasion of neutrophil killing by Streptococcus agalactiae isolated from clinical mastitis bovine, Veterinary Microbiology 2022
7. NADPH oxidase-derived reactive oxygen species production activates the ERK1/2 pathway in neutrophil extracellular traps formation by Streptococcus agalactiae isolated from clinical mastitis bovine, Veterinary Microbiology 2022
8. Vaccine adjuvant platform and fluorescence imaging of amphiphilic γ-PGA-IMQ-LA-FL conjugates, Materials Advances 2022
9. Biodegradable Imiquimod-Loaded Mesoporous Organosilica as a Nanocarrier and Adjuvant for Enhanced and Prolonged Immunity against Foot-and-Mouth Disease Virus in Mice, ACS Applied Bio Materials 2022
10. Zr (IV)-based metal-organic framework nanocomposites with enhanced peroxidase-like activity as a colorimetric sensing platform for sensitive detection of hydrogen peroxide and phenol, Environmental Research 2022
11. Synergetic integration of catalase and Fe3O4 magnetic nanoparticles with metal organic framework for colorimetric detection of phenol, Environmental Research 2022
12. Vacuum Foam Drying Method Improved the Thermal Stability and Long-Term Shelf Life of a Live Attenuated Newcastle Disease Virus Vaccine, AAPS PharmSciTech 2022
13. Role of long polar fimbriae type 1 and 2 in pathogenesis of mammary pathogenic Escherichia coli, Journal of Dairy Science 2021
14.基于金属有机骨架的生物复合物抗逆性研究进展,生物工程学报2021
15.抗菌肽S807 提高仔猪生产性能的研究, 中国猪业2021
16. Live vaccine preserved at room temperature: Preparation and characterization of a freeze-dried classical swine fever virus vaccine, Vaccine 2020
17. Cadmium exacerbates dextran sulfate sodium-induced chronic colitis and impairs intestinal barrier, Science of The Total Environment 2020
18. Development of a water-in-oil-in-water adjuvant for foot-and-mouth disease vaccine based on ginseng stem-leaf saponins as an immune booster Comparative Immunology, Microbiology and Infectious Diseases 2020
19.人参皂苷乳剂的急性毒力研究,吉林畜牧兽医 2020
20.苏北地区某奶牛场乳房炎顽固病原菌的分离鉴定及耐药性分析,江西农业学报 2020
21. T7 噬菌体穿孔素的克隆表达及对宿主损伤研究,江苏农业科学2020
22.猪瘟耐热活疫苗节能冻干曲线的优化研究,江苏农业科学 2020
23.产低毒性脂多糖大肠杆菌J5 基因重组株的构建,江苏农业科学2020
24.国内外奶牛疫病预警监测技术发展现状,中国动物检疫2020
25. Immunomodulatory effects of Alhagi honey polysaccharides encapsulated into PLGA nanoparticles, Carbohydrate polymers 2019
26. Long polar fimbriae contribute to pathogenic Escherichia coli infection to host cells, Applied microbiology and biotechnology 2019
27. Isolation, antibiotic-resistance and conservative antigen analysis of cow mastitis related pathogens from one dairy farm at jiangsu province. 2019
28.猪伪狂犬病病毒IgA 抗体间接ELISA 检测方法的建立,中国兽医科学 2019
29.血清4 型禽腺病毒fiber-2 基因在昆虫细胞中的表达及其免疫原性分析. Chinese Journal of Preventive Veterinary Medicine/Zhongguo Yufang Shouyi Xuebao 2019
30.江苏某牛场生牛乳中肺炎克雷伯菌和鲍曼不动杆菌的分离鉴定,耐药性和毒力分析,中国兽医学报 2019
31.通用型H5 亚型禽流感病毒亚单位疫苗抗原表达和免疫效力研究,病毒学报 2019
32.新型猪瘟耐热活疫苗冻干工艺设计及放大研究, Journal of Agricultural Science & Technology (1008-0864) 2019
33.禽腺病毒I 群4 型疫苗研究态势分析--专利布局的视角,农业与技术2019
34.江苏某牛场奶牛乳房炎病原菌的分离鉴定,耐药性及保守抗原分析,扬州大学学报:农业与生命科学版 2019
35. Engineering T7 bacteriophage as a potential DNA vaccine targeting delivery vector,Virology journal 2018
36. Development of a novel oil-in-water emulsion and evaluation of its potential adjuvant function in a swine influenza vaccine in mice, BMC veterinary research 2018
37.高效液相色谱法测定人参皂苷复乳中人参皂苷含量 中兽医医药杂志, 2018
38. Heat resistant formulation screening and freeze-drying process strategy design of duck virus hepatitis vaccine. Southwest China Journal of Agricultural Sciences 2017
39. Treatment effect of a flavonoid prescription on duck virus hepatitis by its hepatoprotective and antioxidative ability, Pharmaceutical Biology 2017
40. Immunogenicity of T7 bacteriophage nanoparticles displaying GH loop of foot-and-mouth disease virus (FMDV), Veterinary microbiology 2017
41. T7 噬菌体p10 融合蛋白表达及自组装VLP 观察,江西农业学报 2017
42.兽用疫苗佐剂的研究进展,畜牧兽医科学:电子版 2017
43.县域范围内猪瘟疫苗免疫效果的监测与研究,江西农业学报 2017
44.鸭病毒性肝炎活疫苗的耐热冻干工艺策略设计. Southwest China Journal of Agricultural Sciences 2017
45. Swine fever vaccine freeze-drying technology without gelatin and protein formulation. Chinese Journal of Veterinary Science 2016
46. Preparation and heat resistance study of porcine reproductive and respiratory syndrome virus sugar glass vaccine, Vaccine 2016
47.鸡新城疫活疫苗室温保存工艺的初步研究, Journal of Agricultural Science & Technology (1008-0864) 2016
48.猪瘟无明胶无蛋白耐热活疫苗的研制及冻干工艺,中国兽医学报2016
49. VP 4 和VP 5 蛋白在鸡传染性法氏囊病毒感染, Vero 细胞中的作用,南京农业大学学报 2016
50. Studies on room temperature preservation technology of porcine reproductive and respiratory syndrome vaccine. Journal of Agricultural Science and Technology (Beijing) 2015
51. Optimization on preparation conditions of salidroside liposome and its immunological activity on PCV-2 in mice, Evidence-Based Complementary and Alternative Medicine 2015
52.猪繁殖与呼吸综合征疫苗室温保存工艺的研究,中国农业科技导报 2015
53.转运真核表达盒的重组T7 噬菌体构建,江苏农业学报 2015
54.猪繁殖与呼吸综合征糖玻璃活疫苗制备及其耐热性能的初步研究,畜牧与兽医 2015
55.甘草次酸脂质体对OVA 免疫小鼠免疫应答的影响,浙江农业学报 2015
56.囊素对鸡传染性法氏囊病弱毒苗免疫的影响,黑龙江畜牧兽医2014
57.合成囊素三肽对猪瘟疫苗免疫效果的影响,广东畜牧兽医科技2014
58.牛磺酸对不同饲养方式蛋鸡肾脏功能,抗氧化能力和细胞因子水平的影响,天津农学院学报 2014
59.牛磺酸对绿壳蛋鸡生长性能和健康状况相关指标的影响,南京农业大学学报 2014
60.一株江苏新型鸭肝炎病毒的鉴定,浙江农业学报 2014
61. Optimization on preparation condition of propolis flavonoids liposome by response surface methodology and research of its immunoenhancement activity, Evidence-based complementary and alternative medicine 2013
62.海兰褐蛋鸡体内Toll 样受体的分子克隆与序列分析,中国动物传染病学报 2013
63.疫苗的泡沫冷冻干燥研究,浙江大学学报:农业与生命科学版2013
64.一株小鹅瘟病毒的分离与鉴定,中国家禽 2013
65.鸡Toll 样受体在IBDV 免疫中的作用研究,广东畜牧兽医科技2013
66. TLR3 激动剂对鸡IBDV 活疫苗免疫的影响 , 江苏农业科学2013
67.不同结构对囊素样肽的免疫活性影响,中国兽医学报2012
68.牛磺酸对急性热应激蛋鸡输卵管损伤的保护作用,江苏农业学报2011
69.补中益气汤对雏鸡免疫功能的影响,中兽医学杂志 2011
70.猪高热病的防控策略，兽医导刊，2011
71. CpG 寡核苷酸增强鸡新城疫疫苗免疫效力的研究，中国动物传染病学报，2010
72.抗菌肽S807 提高肉鸡生产性能的研究，广东畜牧兽医科技 2010
73.硫酸化黄芪多糖对CEF 生长及抵抗IBDV 感染的影响，南京农业大学学报，2009
74. 12 种藏药对鸡胚成纤维细胞的安全浓度和生长的影响，中国兽医学报，2009
75.硫酸化淫羊藿多糖对鸡外周血淋巴细胞IL-2 和IFN-γ 的mRNA 表达的影响，江苏农业学报，2009
76. 3 种藏药材方剂对鸡感染新城疫病毒的临床疗效，畜牧与兽医，2009
77.硫酸化黄芪多糖佐剂活性的比较，中国兽医学报，2009
78.正交实验优选黄芪多糖硫酸化修饰条件及修饰产物抗IBDV 活性测定，中药材，2008
79.淫羊藿多糖的硫酸化修饰及其对IBDV 感染细胞的影响，畜牧兽医学报，2008
80.淫羊藿多糖硫酸化修饰条件的优化，中草药 ，2008
81.黄芩解毒散灌胃对小鼠的急性和亚慢性毒性试验，中国实验方剂学杂志，2008
82.分煎和合煎对中药乳康灌注液治疗奶牛乳腺炎效果的影响，畜牧与兽医，2008
83.中药对三黄肉鸡皮肤颜色和组织中类胡萝卜素含量的影响，江苏农业学报，2007
84.三黄肉鸡对中药色素吸收规律的研究，畜牧与兽医，2007
85.两种家兔血常规和血液流变学参数的正常值，畜牧与兽医，2006
86.奶牛子宫内膜炎病原菌的分离鉴定及中药的抑菌作用，畜牧与兽医，2005
87.不同中药对奶牛乳房炎病原菌体外抑制作用的比较，畜牧与兽医，2005