卢宇
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卢宇,博士,研究员,江苏省第十二批“六大高峰人才”, 江苏省农业科学院“十三五”第一批青年拔尖人才。动物免疫工程研究所副所长,疫苗抗原创制研究室主任,兼职南京农业大学硕士生导师。从事疫苗佐剂与耐热保护剂技术的研究,主持承担国家自然科学基金、江苏省农业科技自主创新资金项目等省部级以上课题4项;以第一完成人获国家发明专利6项,以第一作者或通讯作者发表论文30余篇,参编(译)著作4部。
一、主持科研项目
1.主持国家自然科学基金课题“鸡传染性法氏囊病毒VP4和VP5蛋白抑制机体I型干扰素信号通路的探索”,2013-2015;
2. 主持农业部公益性行业专项子课题“猪免疫抑制性瘟病辩证施治关键技术研究与示范”,2014-2018;
3. 主持江苏省农业科技自主创新资金“猪圆环病毒疫苗新型水包油佐剂的开发”,2013-2015;
4.主持江苏省六大人才高峰项目“活疫苗室温保存技术的研究”,2015-2017。
二、获得专利授权(第1完成人)
1.一种复方免疫佐剂及疫苗,ZL 201010190806.3;
2. 囊素样多肽衍生物作为复方猪瘟疫苗免疫增强剂的应用,ZL 201310489683.7;
3. 一种耐热保护剂及其应用, ZL 201310004607.2;
4. 鹅细小病毒及其应用,ZL 201310489683.7;
5. 兽用药物的复乳型载体及其应用,ZL 2014106076752;
6. 一种环糊精酯化衍生物、制备方法及其应用,ZL 2014103463984;
三、代表性论文
[1] Lv Fang, Lu Yu, Hao Zheng-lin, Zhao Yan-hong, Zhang li-hang, Feng Lei, Chen Jin,Wang Li-li, Rui Rong, Hou Ji-bo. Preparation and heat resistance study of porcine reproductive and respiratory syndrome virus sugar glass vaccine[J].Vaccine ,2016,34 :3746-3750
[2] Yibo Feng, Xiaojuan Zhao, Fang Lv, Jinqiu Zhang, Bihua Deng, Yanhong Zhao, Yuanliang Hu, DeyunWang, Jiaguo Liu, Yu Lu, Ruonan Bo, and Zhenguang Liu,Optimization on Preparation Conditions of Salidroside Liposome and Its Immunological Activity on PCV-2 in Mice[J].Evidence-Based Complementary and Alternative Medicine,2015
[3] Yijun Du, Yu Lu, Xinglong Wang, Jing Qi, Jiyu Liu, Yue Hu, Feng Li, Jiaqiang Wu, Lihui Guo, Junzhen Liu, Haiying Tao, Wenbo Sun, Lei Chen, Xiaoyan Cong, Sufang Ren, Jianli Shi, Jun Li, Jinbao Wang, Baohua Huang, Renzhong Wan. Highly Efficient Expression of Interleukin-2 under the Control of Rabbit b-Globin Intron II Gene Enhances Protective Immune Responses of Porcine Reproductive and Respiratory Syndrome (PRRS) DNA Vaccine in Pigs[J].PLoS ONE,2014 9(3): e90326.
[4] Yun Yu, Yu Lu, Ruonan Bo, Yee Huanga, Yuanliang Hu, Jiaguo Liu, Yi Wu,Yang Tao, Deyun Wang. The preparation of gypenosides liposomes and its effects on theperitoneal macrophages function in vitro[J].International Journal of Pharmaceutics 460 (2014) :248- 254
[5] Xiaojuan Zhao, Yu Lu, Yang Tao, Yee Huang, DeyunWang, Yuanliang Hu, Jiaguo Liu, YiWu,Yun Yu, Cui Liu. Salidroside liposome formulation enhances the activity of dendritic cells and immune responses[J]. International Immunopharmacology ,2013,17:1134-1140
[6] Ju Yuan, Yu Lu, Saifuding Abula, Yuanliang Hu, Jiaguo Liu, Yunpeng Fan, Xiaojuan Zhao, DeyunWang, Xu Liu, and Cui Liu. Optimization on Preparation Condition of Propolis Flavonoids Liposome by Response Surface Methodology and Research of Its Immunoenhancement Activity[J].Evidence-Based Complementary and Alternative Medicine,2013
[7] Yunpeng Fan, Yu Lu, Deyun Wang, Jiaguo Liu, Xiaoping Song, Weimin Zhang, Xiaojuan Zhao, The Luong Nguyena, Yuanliang Hu. Effect of epimedium polysaccharide-propolis flavone immunopotentiator on immunosuppression induced by cyclophosphamide in chickens[J].Cellular Immunology 2013,281:37-43
[8] Yijun Du, Yu Lu, Jing Qi, Jiaqiang Wu, Guisheng Wang,Jinbao Wang. Complete Genome Sequence of a Moderately Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Variant Strain[J].J. Virol. 2012, 86(24):13883.
[9] 赵艳红,吕芳,潘孝青,邓碧华,张金秋,卢宇,侯继波. 鸭病毒性肝炎活疫苗的耐热冻干工艺策略设计[J].西南农业学报,2017,30(7):1680-1685.
[10] 吕芳,赵艳红,张小飞,王丽丽,彭苗苗,郝政林,张金秋,邓碧华,卢宇,侯继波. 猪瘟无明胶无蛋白耐热活疫苗的研制及冻干工艺[J].中国兽医学报,2016,36(12):2014-2018.
[11] 郝政林,吕芳,卢宇,赵艳红,王丽丽,侯继波,芮荣. 猪繁殖与呼吸综合征疫苗室温保存工艺的研究[J].中国农业科技导报,2015,17( 3) : 175-181
[12] 卢宇,赵晓娟,黄叶娥,余韵,王德云. 甘草次酸脂质体对OVA 免疫小鼠免疫应答的影响[J].浙江农业学报,2015,27( 8) : 1345-1349.
[13]张绍志,施铭耀,陈光明,吕芳,卢宇. 疫苗的泡沫冷冻干燥研究[J].浙江大学学报:农业与生命科学版, 2013, 39(3):351-354
[14] 卢宇,张娣,张金秋,邓碧华,吕芳,侯继波. 鸡Toll 样受体在IBDV 免疫中的作用研究[J].广东畜牧兽医科技,2013,38 (1):26-29
[15] 卢宇,邓碧华,吕芳,张娣,张金秋,侯继波. 海兰褐蛋鸡体内Toll 样受体的分子克隆与序列分析[J].中国动物传染病学报,2013,21(2): 45-50